精神疾患は産業への影響が甚大で、その徴候の検出、早期発見、早期介入を可能にする技術開発は有用である。非実験的環境において長時間のデータ取得を行い、より実環境に即した状況でのデータ収集を通して、生体信号と抑うつやストレスとの関係を明らかにすることが我々の目標である。多様な学問分野を超え、抑うつやストレス状態についてより深い知見を獲得することで、精神疾患に由来する社会課題の解決を目指したい。

I think the research and career prospects for microbiologists are diverse and the field continues to evolve with advancement in technology and our understanding of microorganisms. As I am working with microorganisms beneficial to the human health, I would like to continue to pursue careers in academia, working at the Keio University Honda Laboratory, to conduct research on various aspects of microbiology and contribute to scientific advancements. Another pathway I could take is to work at the Keio University Hospital, to analyze patient samples to identify and treat infections. I would like to contribute to epidemiological studies and public health efforts.

My research focuses on identifying the causal genes for adolescent idiopathic scoliosis (AIS) and clarifying their pathogenesis. This involves encapsulating the identification of novel loci, enhancing understanding of genetic architecture, and gaining insights into potential biological mechanisms. As I advance in my career, I aspire to contribute to the development of study for AIS and use my findings to potentially drive innovations in medical genetics.

I have been dedicated to myopia research for the past two years because the complications of myopia bring a great burden to people’s quality of life and social economy. With the development of society and the popularization of electronic products, simple myopia seems to be inevitable. However, simple myopia does not suddenly transform into pathological myopia, and there should be a gradual deterioration process during this period, my research is searching for such a state and indicator to gain a deeper understanding and prevent complications of myopia, improve the lifelong quality of life of myopic individuals.
I have been an ophthalmologist for 10 years before, so I have a better understanding of clinical needs. I will promote my research results in the clinic in the future.

採択期間を通じて腸内細菌叢に対するアプローチを広く学び、様々な疾患に対する新規治療、創薬のヒントを導き出せるような研究を生み出していきたいです。

再生医療研究において、正常の成体の恒常性への理解は重要であり、オルガノイドは生体由来の幹細胞を用いて自己組織能をもつヘテロな細胞群を作るin vitro系として注目されている。小腸絨毛構造を模した培養系の確立は、従来の薬剤ハイスループット系に比べ、よりin vivoとin vitroのギャップを小さくする。特定の細胞の限られた機能だけでなく、異種細胞が共存することで生体再現度を上昇し、細胞研究の信頼度上昇が期待されている。

大学教員、研究者

My name is Shi Jue, and I am currently a second-year student of Ph.D. in the photobiology lab, department of Ophthalmology, Keio University. My research focuses on the relationship between immune cells in the choroid and myopia development. Until now, the experiment results have shown that degranulation of immune cells on the choroid releases pro-inflammatory factors, leading to inflammation of the choroid and ultimately cause myopia development. Some immune cell stabilizers or inhibitors enable to inhibit the development of myopia by inhibiting axial length elongation. Because there are a lot of immune cells in the choroid, in the future study, I am going to focus on the choroidal microenvironment and want to summarize the effects of every immune cell on myopia development.

本研究が組織採取や疾患モデルの開発が問題となる様々な疾患の新たな研究・治療戦略開発の一助になればと思う。自身の将来像としては、今後も実際の臨床現場に赴き問題点に対峙することで、患者および医療現場のニーズに沿った新たな診断・治療法開発のアイデアを生みつつ、他分野の人材とも連携し、より大きな規模の研究を主導できる立場になり、様々な研究者のアイデアを社会に生かせるような仕組み作りに寄与したい。