Doctor and researcher

I am looking forward to being an excellent researcher in this four years,including publishing some ectraodinary publications which is applicable for the society and clinical work.In my research, I hope to solve the problems caused by genetic diseases that affect vision, and solve these problems at the genetic level through gene editing, modification and other technologies.

During preimplantation development, rapid epigenetic changes occur, and key transcription factors, such as “double homeobox” (DUX), drive zygotic genome activation (ZGA) in 2-cell embryos. The ATP-dependent chromatin remodeler SMARCA4 plays a crucial role, as its deletion leads to a two-cell arrest, emphasizing its importance in the 2-cell stage. My research ia focussed on the chromatin remodeler SMARCA4 and its interaction with DUX, impacting the upregulation of 2C-genes and DUX in 2-cell-like cells (2CLCs). Additionally, I seek to deepen our understanding of how SMARCA4 and DUX collaborate to regulate totipotent gene expression, focusing on the significant 2-cell stage. I hypothesize that SMARCA4 is responsible for opening the chromatin to activate master regulators such as DUX or OBOX4. This activation is proposed to involve a subsequent interaction of SMARCA4 with DUX, facilitating the accessibility of 2C-genes like Zscan4 and MERVL for transcription.