Evolutionary divergent ERVs insertion shapes host transcriptome during preimplantation development.RNA-seq analysis showed that ZGA in hamster occurs at the two-cell stage, similar to that in mice. Furthermore, interspecies comparisons of human, hamster, and mouse early embryonic transcriptomes revealed that ZGA genes and their expression dynamics are highly species-specific. Furthermore, evolutionarily young hamster-specific ERV1 and ERVK factors are enriched near the hamster ZGA locus, and these ERVs provide species specificity, suggesting that this may drive ZGA and control the expression of endogenous genes.

My research is focused on investigating the influence of the gut microbiota on the metabolism of steroids. Hormonal steroids encompass adrenal cortical hormones, sex hormones, and cholesterol and all of them play important roles in the host. By studing the regulation of gut microbiota to steroids we know more about the relationship among gut microbiota, steroids and multi-organ crosslinks.

My research focuses on the relationship between the fatty liver index (FLI) and the development of cardiovascular disease. However, the goal is not only to understand the relationship between the FLI and cardiovascular disease, but more importantly how to use the FLI to screen people simply and effectively at high risk and provide early intervention in a timely manner. I hope that the FLI will be able to be applied in large-scale health check-ups or screenings and that it will be able to screen people who are at a higher risk of developing cardiovascular diseases in the future.

私は現在、医学研究科にてwell-beingの観点からさまざまなデータ検証を行わせていただいております。同時に、医学部で医学を学ばせていただいており、将来的にはこれらの知を融合し、複合的な視座を持って社会に貢献していきたいと考えております。

研究者として薬理学研究の専門知識と技術を活かし、大学や研究機関で研究者として活動することを目指します。新たな薬物の開発や創薬研究、薬物の効果や副作用のメカニズムの解明など、学問的な視点からの研究に従事します。

将来薬理学の知識と技術を利用し、製薬企業で新薬の開発や既存薬の改良、技術開発やプロダクトデザインなどに携わることを目指します。

精神疾患は産業への影響が甚大で、その徴候の検出、早期発見、早期介入を可能にする技術開発は有用である。非実験的環境において長時間のデータ取得を行い、より実環境に即した状況でのデータ収集を通して、生体信号と抑うつやストレスとの関係を明らかにすることが我々の目標である。多様な学問分野を超え、抑うつやストレス状態についてより深い知見を獲得することで、精神疾患に由来する社会課題の解決を目指したい。

I think the research and career prospects for microbiologists are diverse and the field continues to evolve with advancement in technology and our understanding of microorganisms. As I am working with microorganisms beneficial to the human health, I would like to continue to pursue careers in academia, working at the Keio University Honda Laboratory, to conduct research on various aspects of microbiology and contribute to scientific advancements. Another pathway I could take is to work at the Keio University Hospital, to analyze patient samples to identify and treat infections. I would like to contribute to epidemiological studies and public health efforts.

My research focuses on identifying the causal genes for adolescent idiopathic scoliosis (AIS) and clarifying their pathogenesis. This involves encapsulating the identification of novel loci, enhancing understanding of genetic architecture, and gaining insights into potential biological mechanisms. As I advance in my career, I aspire to contribute to the development of study for AIS and use my findings to potentially drive innovations in medical genetics.

私は公衆衛生学上の課題への取り組みを通して心血管性疾患などの重篤な疾病の予防に関する知見を深め、健康寿命の延伸に貢献することを目標としております。現在取り組んでいる課題は金属曝露と生活習慣病に関する関連の解析で、多層オミクス解析も組み合わせることにより、特定の生活習慣と生活習慣病の関連や発症機序について新たな示唆を得ることができ、これまでとは異なる予防についての展望が拓けることを期待しています。